Thiamine chlorideCAS：59-43-8

Critical Role in Carbohydrate Metabolism

Thiamine serves as an indispensable cofactor in key biochemical pathways, leveraging its coenzymatic properties to promote the transformation of carbohydrates into metabolically usable energy substrates.

Maintenance of Neurological Integrity

This essential micronutrient plays a pivotal role in sustaining normal neural tissue physiology and inhibiting the onset of various neurological disorders.

Enhancement of Cardiac Performance

Thiamine contributes to the preservation of optimal myocardial function, while also supporting the efficient regulation of circulatory system dynamics.

Improvement of Digestive Efficiency

It enhances gastrointestinal tract function by boosting enzymatic catalytic activity and facilitating the effective absorption and utilization of nutrients.

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Vitamin B1, frequently referred to as thiamine or thiamine hydrochloride, is a vital component of the B-vitamin family. This essential micronutrient plays a key role in regulating carbohydrate metabolism and acts as a foundational requirement for sustaining normal neurological signal transmission, myocardial function, and gastrointestinal tract operations.

Through the process of phosphorylation with adenosine triphosphate (ATP), vitamin B1 is converted into thiamine pyrophosphate—also known as cocarboxylase—which serves as an irreplaceable coenzyme in the biochemical pathways governing carbohydrate metabolism.

Thiamine chlorideCAS：59-43-8

Melting point	248 °C (decomp)
density	1.3175 (rough estimate)
refractive index	1.5630 (estimate)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	DMSO : 6 mg/mL (19.95 mM)
form	Solid
color	White to off-white
InChI	InChI=1S/C12H17N4OS.ClH/c1-8-11(3-4-17)18-7-16(8)6-10-5-14-9(2)15-12(10)13;/h5,7,17H,3-4,6H2,1-2H3,(H2,13,14,15);1H/q+1;/p-1
InChIKey	MYVIATVLJGTBFV-UHFFFAOYSA-M
SMILES	O([H])CCC1=C(C)[N+](=CS1)CC1C=NC(=NC=1N)C.[Cl-]
LogP	-3.930 (est)
CAS DataBase Reference	59-43-8(CAS DataBase Reference)
EPA Substance Registry System	Thiamine (59-43-8)
Safety Information
Hazardous Substances Data	59-43-8(Hazardous Substances Data)

Thiamine chlorideCAS：59-43-8

Insufficiency of this coenzyme disrupts the normal progression of oxidative metabolism, triggering the abnormal buildup of pyruvate and lactate. This metabolic disturbance in turn impairs the efficiency of cellular energy generation processes.

Additionally, vitamin B1 exhibits inhibitory effects on cholinesterase activity. In states of thiamine deficiency, heightened cholinesterase activity accelerates the degradation of acetylcholine—a key neurotransmitter—thereby compromising the efficiency of neural signal transmission. These neurochemical alterations subsequently induce functional abnormalities in the gastrointestinal and cardiac systems.

Thiamine chlorideCAS：59-43-8